| 货号 | 14413-1mg |
| 描述 | HA-1100, a cell-permeable hydroxylated metabolite of HA-1077 (Item No. 10010559), is a potent inhibitor of Rho-associated kinase (ROCK) (Ki = 150 nM).1 It less effectively inhibits protein kinase A (Ki = 2.2 μM).1 It has been used to explore the role of ROCK in hypoxic and ischemic signaling as well as arterial relaxation.2,3,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Jacobs, M.,Hayakawa, K.,Swenson, L., et al. The structure of dimeric ROCK I reveals the mechanism for ligand selectivity. The Journal of Biological Chemisty 281(1), 260-268 (2006). 2.Nakamura, K.,Nishimura, J.,Hirano, K., et al. Hydroxyfasudil, an active metabolite of fasudil hydrochloride, relaxes the rabbit basilar artery by disinhibition of myosin light chain phosphatase. Journal of Cerebral Blood Flow and Metabolism 21(7), 876-885 (2001). 3.Takemoto, M.,Sun, J.,Hiroki, J., et al. Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase. Circulation 106(1), 57-62 (2002). 4.Wolfrum, S.,Dendorfer, A.,Rikitake, Y., et al. Inhibition of rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection. Arteriosclerosis, Thrombosis, and Vascular Biology 24(10), 1842-1847 (2004). 5.Satoh, S.i.,Utsunomiya, T.,Tsurui, K., et al. Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage. Life Sciences 69(12), 1441-1453 (2001). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 343.8 |
| 分子式 | C14H17N3O3S • HCl |
| CAS号 | 155558-32-0 |
| 稳定性 | ≥ 2 years |
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