AGK2
货号：
13145-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 13145-1mg |
| 描述 | Mammalian sirtuin 2 (SIRT2) is a nicotinamide adenine dinucleotide-dependent histone deacetylase (HDAC) with roles in cell cycle progression and tumorigenesis. AGK2 is a cell-permeable, selective inhibitor of SIRT2 (IC50 = 3.5 μM) that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.1 It rescues dopamine neurons from α-synuclein toxicity in both in vitroandin vivo Parkinson’s disease models, mimicking the effect of siRNA-mediated blockade of SIRT2 expression.1 AGK2 may be a useful tool for studying the roles of SIRT2 in neurodegeneration and aging, as well as cell cycle progression and tumorigenesis. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Outeiro, T.F.,Kontopoulos, E.,Altmann, S.M., et al. Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson’s Disease. Science 317, 516-519 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 434.3 |
| 分子式 | C23H13Cl2N3O2 |
| CAS号 | 304896-28-4 |
| 稳定性 | ≥ 2 years |
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