| 货号 | 13109-25mg |
| 描述 | Emodin is a naturally-occurring anthraquinone found in a variety of plants used in traditional Chinese medicine. Purified emodin has diverse effects, including the suppression of inflammation, dyslipidemia, and cancer.1,2,3 At a molecular level, emodin directly and selectively inhibits casein kinase II (IC50 = 0.89 μM).4,5 Through this action, it inhibits the COP9 signalosome, causing the stabilization of the tumor suppressor p53.5 Moreover, emodin acts as a phytoestrogen, binding human estrogen receptors and blocking 17β-estradiol binding with Ki values of 0.77 and 1.5 μM for ERα and ERβ, respectively.6 |
| 别名 | Archin;Frangulic Acid;NSC 408120;NSC 622947;Schuttgelb; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tzeng, T.F.,Lu, H.J.,Liou, S.S., et al. Emodin, a naturally occurring anthraquinone derivative, ameliorates dyslipidemia by activating AMP-activated protein kinase in high-fat-diet-fed rats. Evidence-Based Complementary and alternative Medicine 2012, 1-9 (2012). 2.Alisi, A.,Pastore, A.,Ceccarelli, S., et al. Emodin prevents intrahepatic fat accumulation, inflammation and redox status imbalance during diet-induced hepatosteatosis in rats. International Journal of Molecular Sciences 13, 2276-2289 (2012). 3.Lin, S.Z.,Wei, W.T.,Chen, H., et al. Antitumor activity of emodin against pancreatic cancer depends on its dual role: Promotion of apoptosis and suppression of angiogenesis. PLoS One 7(8), 1-15 (2012). 4.Sarno, S.,De Moliner, E.,Ruzzene, M., et al. Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA). Biochemistry Journal 374, 639-646 (2003). 5.Füllbeck, M.,Huang, X.,Dumdey, R., et al. Novel curcumin- and emodin-related compounds identified by in silico 2D/3D conformer screening induce apoptosis in tumor cells. BMC Cancer 5(97), 1-14 (2005). 6.Matsuda, H.,Shimoda, H.,Morikawa, T., et al. Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): Structure-requirement of hydroxyanthraquinones for estrogenic activity. Bioorganic & Medicinal Chemistry Letters 11(14), 1839-1842 (2001). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 270.2 |
| 分子式 | C15H10O5 |
| CAS号 | 518-82-1 |
| 稳定性 | ≥ 2 years |
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