Ro 01-6128
货号：
11991-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 11991-1mg |
| 描述 | Glutamate, the major excitatory neurotransmitter in the CNS, activates eight known subtypes of metabotropic glutamate receptors (mGluRs). Highly selective modulators designed to act at allosteric sites on certain mGluR subtypes are being developed to preferentially regulate subtype-specific, glutamate-induced receptor activation.1 Ro 01-6128 is a positive allosteric modulator of mGluR1 that can potentiate glutamate-induced calcium release at rat mGluR1a with an EC50 value of 104 nM.2,3 Ro 01-6128 activates ERK1/2 phosphorylation in the absence of exogenously added glutamate with an EC50 value of 248 nM and potentiates glutamate-induced cAMP production with an EC50 value of 21.5 μM.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sheffler, D.J., and Conn, P.J. Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells. Neuropharmacology 55(4), 419-427 (2008).
2.Knoflach, F.,Mutel, V.,Jolidon, S., et al. Positive allosteric modulators of metabotropic glutamate 1 receptor: Characterization, mechanism of action, and binding site. Proceedings of the National Academy of Sciences of the United States of America 98(23), 13402-13407 (2001).
3.Hemstapat, K.,de Paulis, T.,Chen, Y., et al. A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Molecular Pharmacology 70(2), 616-626 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 283.3 |
| 分子式 | C17H17NO3 |
| CAS号 | 302841-86-7 |
| 稳定性 | ≥ 2 years |
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