SB 297006
货号：
11964-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 11964-1mg |
| 描述 | SB 297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ.1 It is at least 250-fold selective for CCR3 over a panel of other chemokine receptors. SB 297006 blocks CCR3-mediated calcium mobilization induced by eotaxin, eotaxin-2, and MCP-4 in transfected cells.1 It suppresses antigen-induced accumulation of Th2 lymphocytes and eosinophils in lungs of mice when delivered subcutaneously (100 mg/kg).2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.White, J.R.,Lee, J.M.,Dede, K., et al. Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. J. Biol. Chem. 275(47), 36626-36631 (2000).
2.Mori, A.,Ogawa, K.,Someya, K., et al. Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists. Int. Immunol. 19(8), 913-921 (2007).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥99% |
| 计算分子量 | 342.4 |
| 分子式 | C18H18N2O5 |
| CAS号 | 58816-69-6 |
| 稳定性 | ≥ 1 year |
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