| 货号 | 10638-1mg |
| 描述 | FLLL32 is a cell-permeable analog of curcumin (Item No. 81025) that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells (IC50 = ~ 5 µM).1,2 It blocks signaling from IFN-α or IL-6 through JAK2/STAT3 and induces apoptosis in several types of cancer cells.1,2 FLLL32 does not interfere with IFN-γ-induced STAT1 signaling and does not adversely affect the function or viability of immune cells.1 Through its effects on JAK2/STAT3 signaling, FLLL32 enhances the chemo- and radiosensitivity of cancer cells.2,3,4 |
| 别名 | JAK2 Inhibitor X; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bill, M.A.,Fuchs, J.R.,Li, C., et al. The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity. Mol. Cancer 9(165), (2010). 2.Lin, L.,Hutzen, B.,Zuo, M., et al. Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. Cancer Research 70(6), 2445-2454 (2010). 3.Abuzeid, W.M.,Davis, S.,Tang, A., et al. Sensitization of head and neck cancer to cisplatin through the use of a novel curcumin analog. Arch. Otolaryngol. Head Neck Surg. 137(5), 499-507 (2011). 4.Wu, X.,Tang, W.,Marquez, R.T., et al. Overcoming chemo/radio-resistance of pancreatic cancer by inhibiting STAT3 signaling. Oncotarget 7(10), 11708-11723 (2016). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 464.6 |
| 分子式 | C28H32O6 |
| CAS号 | 1226895-15-3 |
| 稳定性 | ≥ 2 years |
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