15-Lipoxygenase Inhibitor 1
货号：
10010468-500ug 基本售价：
350.0 元 规格：
500 ug
产品信息
概述| 货号 | 10010468-500ug |
| 描述 | Lipoxygenases (LOs) are non-heme iron-containing dioxygenases that catalyze the oxidation of polyunsaturated fatty acids to generate unsaturated fatty acid hydroperoxides.1 The immediate products of 15-LO fatty acid oxidation act as mediators in inflammation, thrombosis, and cancer.2 15-Lipoxygenases (15-LO) inhibitor 1 is a heterocyclic pyrimidobenzothiazine compound that inhibits 15-LO with an IC50 value of 18 µM.3 The inhibitor appears to act as an antioxidant, interfering with the redox cycle of 15-LO.3 |
| 别名 | 15-LO Inhibitor 1; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gaffney, B.J. Lipoxygenases: Structural principles and spectroscopy. Annual Reviews of Biophysical and Biomolecular Structure 25, 431-459 (1996).
2.Chanez, P.,Bonnans, C.,Chavis, C., et al. 15-Lipoxygenase. A janus enzyme? American Journal of Respiration, Cell, and Molecular Biology 27, 655-658 (2002).
3.Bakavoli, M.,Nikpour, M.,Rahimizadeh, M., et al. Design and synthesis of pyrimido[4,5-b][1,4]benzothiazine derivatives, as potent 15-lipoxygenase inhibitors. Bioorganic & Medicinal Chemistry 15, 2120-2126 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 313.4 |
| 分子式 | C16H19N5S |
| CAS号 | 928853-86-5 |
| 稳定性 | ≥ 1 year |
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