WHI-P131
货号：
10011246-1mg 基本售价：
336.0 元 规格：
1 mg
产品信息
概述| 货号 | 10011246-1mg |
| 描述 | Janus kinase 3 (JAK3) is a cytoplasmic protein tyrosine kinase that functions in the initiation of cytokine-triggered signal transduction by catalyzing the phosphorylation of signal transduction and activators of transcription (STATs). JAK3 is abundantly expressed in normal lymphoid cells as well as human lymphoblastic and myeloblastic leukemia cells. Janex 1 selectively inhibits the tyrosine kinase activity of JAK3 with an IC50 value of 78 µM without affecting the enzymatic activity of JAK1, JAK2, or other protein tyrosine kinases (IC50 ≥350 µM).1 Janex 1 induces apoptosis in JAK3-expressing human leukemia cell lines NALM-6 and LC1;19, but not in melanoma or squamous carcinoma cell lines.1 |
| 别名 | WHI-P131; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sudbeck, E.A.,Liu, X.P.,Narla, R.K., et al. Structure-based design of specific inhibitors of janus kinase 3 as apoptosis-inducing antileukemic agents. Clinical Cancer Research 5, 1569-1582 (1999).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 297.3 |
| 分子式 | C16H15N3O3 |
| CAS号 | 202475-60-3 |
| 稳定性 | ≥ 2 years |
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