| 货号 | 11811-1mg |
| 描述 | INK128 is an inhibitor of TORC1/2, acting as an ATP-dependent inhibitor of mTOR kinase (IC50 = 1 nM).1,2,3 It blocks the phosphorylation of downstream substrates of both TORC1 and TORC2.2 INK128 interferes with the growth of cell lines which are resistant to rapamycin and pan-PI3K inhibitors.2,4 Moreover, daily, oral administration of INK128 inhibits angiogenesis and tumor growth in several xenograft models.2 The effects of INK128 on gene expression also reduce invasion and metastasis.5 |
| 别名 | MLN0128; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Liu, Q.,Thoreen, C.,Wang, J., et al. mTOR mediated anti-cancer drug discovery. Drug Discov.Today Ther.Strateg. 6(2), 47-55 (2009). 2.Jessen, K.,Wang, S.,Kessler, L., et al. Abstract B148: INK128 is a potent and selective TORC1/2 inhibitor with broad oral antitumor activity. Molecular Cancer Therapeutics 8, (2009). 3.Schenone, S.,Brullo, C.,Musumeci, F., et al. ATP-competitive inhibitors of mTOR: An update. Current Medicinal Chemistry 18, 2995-3014 (2011). 4.Maiso, P.,Liu, Y.,Morgan, B., et al. Defining the role of TORC1/2 in multiple myeloma. Blood 118(26), 6860-6870 (2011). 5.Hsieh, A.C.,Liu, Y.,Edlind, M.P., et al. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature 485, 55-61 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 309.3 |
| 分子式 | C15H15N7O |
| CAS号 | 1224844-38-5 |
| 稳定性 | ≥ 2 years |
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