| 货号 | 20928-5mg |
| 描述 | Desacetyl bisacodyl (DAB) is an active metabolite of two stimulant laxatives, bisacodyl and sodium picosulfate.1,2 DAB evokes several effects at the colon or rectum, including increased mucus and chloride secretion.3,4 Oral administration of bisacodyl leads to decreased expression of aquaporin-3 in the colon of rats.5 The effects of both DAB and bisacodyl can be blocked with cyclooxygenase (COX) inhibitors, suggesting that products of the COX signaling pathway contribute to laxative effects.4,5 |
| 别名 | DAB;DDPM; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Friedrich, C.,Richter, E.,Trommeshauser, D., et al. Absence of excretion of the active moiety of bisacodyl and sodium picosulfate into human breast milk: an open-label, parallel-group, multiple-dose study in healthy lactating women. Drug Metab. Pharmacokinet. 26(5), 458-464 (2011). 2.Jauch, R.,Hankwitz, R.,Beschke, K., et al. Bis-(p-hydroxyphenyl)-pyridyl-2-methane: The common laxative principle of Bisacodyl and sodium picosulfate. Arzneimittel-Forschung 25(11), 1796-1800 (1975). 3.Farack, U.M.,Gruber, E. and Loeschke, K. The influence of bisacodyl and deacetylbisacodyl on mucus secretion, mucus synthesis and electrolyte movements in the rat colon in vivo. Eur. J. Pharmacol. 117(2), 215-222 (1985). 4.Fujita, T.,Karaki, S.-i.,Tateoka, T., et al. Desacetyl bisacodyl-induced epithelial Cl(−) secretion in rat colon and rectum. Biomed. Res. 37(1), 13-20 (2016). 5.Ikarashi, N.,Baba, K.,Ushiki, T., et al. The laxative effect of bisacodyl is attributable to decreased aquaporin-3 expression in the colon induced by increased PGE2 secretion from macrophages. Am. J. Physiol. Gastrointest. Liver Physiol. 301(5), G887-G895 (2011). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 277.3 |
| 分子式 | C18H15NO2 |
| CAS号 | 603-41-8 |
| 稳定性 | ≥ 2 years |
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