| 货号 | 16793-500mg |
| 描述 | Ibuprofen is a non-steroidal anti-inflammatory drug with diverse biochemical actions, most notably inhibiting COX-1 and COX-2 (IC50s = 2.6 and 1.53, µM, respectively).1 It is commonly synthesized as a racemic mixture of (S)- and (R)-isomers. (S)-Ibuprofen is an enantiomer that more potently inhibits COX activity, thromboxane formation, and platelet aggregation than the (R)-form.2,3 (S)-Ibuprofen also inhibits activation of NF-κB more effectively than (R)-ibuprofen (IC50s = 62 and 122 µM, respectively).4 However, the enantiomers are equipotent in blocking superoxide formation, β-glucuronidase release, and LTB4 generation by stimulated neutrophils (IC50 values range from 0.14 to 0.58 µM).3 A majority of (R)-ibuprofen can be inverted to (S)-ibuprofen in humans after oral administration.5,6,7 |
| 别名 | Dexibuprofen;(+)-Ibuprofen; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Barnett, J.,Chow, J.,Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochimica et Biophysica Acta 1209, 130-139 (1994). 2.Evans, A.M.,Nation, R.L.,Sansom, L.N., et al. Effect of racemic ibuprofen dose on the magnitude and duration of platelet cyclo-oxygenase inhibition: Relationship between inhibition of thromboxane production and the plasma unbound concentration of S(+)-ibuprofen. British Journal of Clinical Pharmacology 31(2), 131-138 (1991). 3.Villanueva, M.,Heckenberger, R.,Strobach, H., et al. Equipotent inhibition by R(−)-, S(+)- and racemic ibuprofen of human polymorphonuclear cell function in vitro. British Journal of Clinical Pharmacology 35(3), 235-242 (1993). 4.Scheuren, N.,Bang, H.,Münster, T., et al. Modulation of transcription factor NF-kappaB by enantiomers of the nonsteroidal drug ibuprofen. British Journal of Pharmacology 123, 645-652 (1998). 5.Lee, E.J.D.,Williams, K.,Day, R., et al. Stereoselective disposition of ibuprofen enantiomers in man. British Journal of Clinical Pharmacology 19, 669-674 (1985). 6.Jamali, F. Pharmacokinetics of enantiomers of chiral non-steroidal anti-inflammatory drugs. European Journal of Drug Metabolism and Pharmacokinetics 13, 1-9 (1988). 7.Evans, A.M. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin.Rheumatol. 20, S9-S14 (2001). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 206.3 |
| 分子式 | C13H18O2 |
| CAS号 | 51146-56-6 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |