| 货号 | 13642-100mg |
| 描述 | Bisphosphonates bind strongly to bone and reduce bone resorption through effects on both osteoclasts and osteoblasts.1,2 Alendronate is a nitrogen-containing bisphosphonate that is commonly used in the treatment of osteoporosis and other metabolic bone diseases.3,4,5 It inhibits bone resorption in vitro with an IC50 value of 2 nM.1In vivo, alendronate significantly increases (or prevents a decrease in) bone mineral density and reduces vertebral fractures.4,5,6 |
| 别名 | Adronat;Fosamax;G-704650;MK-217; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sahni, M.,Guenther, H.L.,Fleisch, H., et al. Bisphosphonates act on rat bone resorption through the mediation of osteoblasts. Journal of Clinical Investigation 91, 2004-2011 (1993). 2.Lin, J.H. Bisphosphonates: A review of their pharmacokinetic properties. Bone 18(2), 75-85 (1996). 3.Patel, S. Current and potential future drug treatments for osteoporosis. Annals of the Rheumatic Diseases 55, 700-714 (1996). 4.Bell, N.H. and Johnson, R.H. Bisphosphonates in the treatment of osteoporosis. Endocrine 6(2), 203-206 (1997). 5.Tuck, S.P. and Datta, H.K. Osteoporosis in the aging male: Treatment options. Clinical Interventions in Aging 2(4), 521-536 (2007). 6.Azuma, Y.,Oue, Y.,Kanatani, H., et al. Effects of continuous alendronate treatment on bone mass and mechanical properties in ovariectomized rats: Comparison with pamidronate and etidronate in growing rats. Journal of Pharmacology and Experimental Therapeutics 286(1), 128-135 (1998). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 325.1 |
| 分子式 | C4H12NO7P2 • H6NaO3 |
| CAS号 | 121268-17-5 |
| 稳定性 | ≥ 2 years |
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