| 货号 | 10010229-100ug |
| 描述 | PAF C-18-d4 contains four deuterium atoms at the 10, 10, 11, and 11 positions. It is intended for use as an internal standard for the quantification of PAF C-18 by GC- or LC-mass spectrometry. PAF C-18 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the “remodeling” and de novopathways.1 It is less potent than PAF C-16 in the induction of platelet aggregation, but equipotent in activation of guinea pig macrophages.2 PAF C-18 induces the release of PGE2 and TXB2 from albumin-elicited guinea pig macrophages, and enhances the spreading of plated macrophages.3 Pathological processes involving PAF include necrotizing enterocolitis,4 inflammation, asthma, and allergy.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Prescott, S.M.,Zimmerman, G.A., and McIntyre, T.M. Platelet-activating factor. The Journal of Biological Chemisty 265, 17381-17384 (1990). 2.Stewart, A.G., and Grigoriadis, G. Structure-activity relationships for platelet-activating factor (PAF) and analogs reveal differences between PAF receptors on platelets and macrophages. Journal of Lipid Mediators 4, 299-308 (1991). 3.Hartung, H.P. Acetyl glyceryl ether phosphorylcholine (platelet-activating factor) mediates heightened metabolic activity in macrophages. Studies on PGE, TXB2 and O2 production, spreading, and the influence of calmodulin-inhibitor W-7. FEBS Letters 160, 209-212 (1983). 4.Wang, H.,Tan, X.D.,Qu, X.W., et al. Platelet-activating factor (PAF) up-regulates plasma and tissue PAF-acetylhydrolase activity in the rat: Effect of cycloheximide. Pediatric Research 42, 597-603 (1997). 5.Sturk, A.,Wouter Ten Cate, J.,Hosford, D., et al. The synthesis, catabolism, and pathophysiological role of platelet-activating factor. Advances in Lipid Research 23, 219-276 (1989). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d4) |
| 计算分子量 | 555.7 |
| 分子式 | C28H54D4NO7P |
| 稳定性 | ≥ 2 years |
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