| 货号 | 11321-1mg |
| 描述 | Cyclopamine is a natural steroidal alkaloid that inhibits signaling through the hedgehog pathway at the level of the pathway activator Smoothened.1,2 By altering gene expression in this signaling sequence, cyclopamine induces defects in morphogenesis, first observed in chicks and sheep as cyclopia.1 As a readout of action, cyclopamine inhibits hedgehog-dependent expression of Pax7 with an IC50 value of 24 nM.1 Although teratogenic during development, cyclopamine has potential applications in the treatment of cancer.3,4,5 |
| 别名 | 11-Deoxojervine;Jervine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Incardona, J.P.,Gaffield, W.,Kapur, R.P., et al. The teratogenic Veratrum alkaloid cyclopamine inhibits Sonic hedgehog signal transduction. Development 125, 3553-3562 (1998). 2.Frank-Kamenetsky, M.,Zhang, X.M.,Bottega, S., et al. Small-molecule modulators of Hedgehog signaling: Identification and characterization of smoothened agonists and antagonists. J.Biol. 1(2), (2002). 3.Xu, F.G.,Ma, Q.Y. and Wang, Z. Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer. Cancer Letters 283, 119-124 (2009). 4.Heretsch, P.,Tzagkaroulaki, L. and Giannis, A. Cyclopamine and hedgehog signaling: Chemistry, biology, medical perspectives. Angewandte Chemie International Edition 49, 3418-3427 (2010). 5.Mahindroo, N.,Punchihewa, C. and Fujii, N. Hedgehog-Gli signaling pathway inhibitors as anticancer agents. Journal of Medicinal Chemistry 52(13), 3829-3845 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 411.6 |
| 分子式 | C27H41NO2 |
| CAS号 | 4449-51-8 |
| 稳定性 | ≥ 2 years |
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