| 货号 | 13010-1mg |
| 描述 | PGE1 is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic acid (DGLA), but it is virtually undetectable in the plasma of normal humans or other animals.1 Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC50 of PGE1 for the inhibition of ADP-induced human platelet aggregation is 40 nM.2,3 The vasorelaxant and anti-hypertensive effects of PGE1 are used to treat male erectile dysfunction and to provide emergency vasodilation of the patent ductus arteriosus in infants whose cardiac anomalies require pulmonary shunting for survival.4,5 In human males, the intracavernosal effective dose range for PGE1 is 2 to 80 µg, and the transurethral range is 125 to 1,000 µg.4 |
| 别名 | Alprostadil;PGE1; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Cawello, W.,Schweer, H.,Dietrich, B., et al. Pharmacokinetics of prostaglandin E1 and its main metabolites after intracavernous injection and short-term infusion of prostaglandin E1 in patients with erectile dysfunction. Journal of Urology 158, 1403-1407 (1997). 2.Kobzar, G.,Mardla, V.,Järving, I., et al. Antiaggregating potency of E-type prostaglandins in human and rabbit platelets. Proceedings of the Estonian Academy of Sciences.Chemistry 40, 179-180 (1991). 3.Okada, F.,Nukada, T.,Yamauchi, Y., et al. The hypotensive effect of prostaglandin E1 on hypertensive cases of various types. Prostaglandins 7, 99-106 (1974). 4.Padma-Nathan, H.,Hellstrom, W.J.G.,Kaiser, F.E., et al. Treatment of men with erectile dysfunction with transurethral alprostadil. New England Journal of Medicine 336, 1-7 (1997). 5.Olley, P.M., and Coceani, F. Prostaglandins and the ductus arteriosus. Annual Reviews of Medicine 32, 375-3785 (1981). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 354.5 |
| 分子式 | C20H34O5 |
| CAS号 | 745-65-3 |
| 稳定性 | ≥ 2 years |
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