| 货号 | 10009569-500ug |
| 描述 | Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.1 It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.2,1,3 (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.1 It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.2,1,3 (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.1 In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.4 |
| 别名 | Seliciclib; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.McClue, S.J.,Blake, D.,Clarke, R., et al. In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine). International Journal of Cancer 102, 463-468 (2002). 2.Meijer, L.,Borgne, A.,Mulner, O., et al. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. European Journal of Biochemistry 243, 527-536 (1997). 3.Havlícek, L.,Hanus, J.,Vesely, J., et al. Cytokinin-derived cyclin-dependent kinase inhibitors: Synthesis and cdc2 inhibitory activity of olomoucine and related compounds. Journal of Medicinal Chemistry 40, 408-412 (1997). 4.Bukanov, N.O.,Smith, L.A.,Klinger, K.W., et al. Long-lasting arrest of murine polycystic kiney disease with CDK inhibitor roscovitine. Nature 444, 949-952 (2006). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 354.5 |
| 分子式 | C19H26N6O |
| CAS号 | 186692-46-6 |
| 稳定性 | ≥ 2 years |
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