CAY10398
货号：
89740-1mg 基本售价：
224.0 元 规格：
1 mg
产品信息
概述| 货号 | 89740-1mg |
| 描述 | CAY10398 is an inhibitor of histone deacetylase (HDAC1) with an IC50 value of 10 µM.1 Similar potency is observed with trapoxin A and B, whereas trichostatin A is more potent inhibitor of the enzyme. Trichostatin A also selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA.2 However, trichostatin A is much more expensive than CAY10398. CAY10398 thus represents a selective and cost-effective compound for the inhibition of HDAC. |
| 别名 | MD 85;PX 089274; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Jung, M.,Hoffmann, K.,Brosch, G., et al. Analogues of Trichostatin A and Trapoxin B as histone deacetylase inhibitors. Bioorganic & Medicinal Chemistry Letters 7, 1655-1658 (1997).
2.Taunton, J.,Hassig, C.A., and Schreiber, S.L. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272, 408-411 (1996).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 293.4 |
| 分子式 | C15H23N3O3 |
| CAS号 | 193551-00-7 |
| 稳定性 | ≥ 2 years |
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