CAY10578
货号：
10011264-1mg 基本售价：
182.0 元 规格：
1 mg
产品信息
概述| 货号 | 10011264-1mg |
| 描述 | Casein Kinase 2 (CK2) is a constitutive protein kinase involved in many signal transduction pathways. CK2 is known to negatively regulate apoptosis, and its activity is increased in many proliferating tissues and tumors, which lends promise as an anticancer drug target. CAY10578 is a potent inhibitor of CK2 with an IC50 value of 0.3 µM.1 This compound is ATP competitive, displaying a Ki value of 0.2 µM and only minimally inhibits the activities of other protein kinases (e.g., GSK3, Cdk5, and MSK1).1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Golub, A.G.,Yakovenko, O.Y.,Prykhodko, A.O., et al. Evaluation of 4,5,6,7-tetrahalogeno-1H-isoindole-1,3(2H)-diones as inhibitors of human protein kinase CK2. Biochemica et Biophysica Acta 1784, 143-149 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 708.8 |
| 分子式 | C10H3I4NO4 |
| CAS号 | 19231-60-8 |
| 稳定性 | ≥ 2 years |
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