3,4-DAA
货号：
10007980-1mg 基本售价：
182.0 元 规格：
1 mg
产品信息
概述| 货号 | 10007980-1mg |
| 描述 | Local catabolism of the amino acid tryptophan by indoleamine 2,3-dioxygenase (IDO) is considered an important mechanism of regulating T-cell immunity. Inhibition of the production of T helper-1 (TH1) cytokines offers a new strategy for treating TH1 mediated autoimmune diseases such as multiple sclerosis. 3,4-DAA is an orally active synthetic derivative of the tryptophan metabolite anthranilic acid. It suppresses antigen-specific proliferation of MBP Ac1-11 TCR CD4+ T-cells. At a concentration of 200 µM, 3,4-DAA reduces IFN-γ, IL-2, IL-12/23 p40, and TNFα in splenocytes from antigen-induced transgenic mice. However, at a concentration of 30 µM, IL-4, and IL-10 levels were increased. Expression of inducible nitric oxide synthase and nitric oxide release from EOC20 cells induced by IFN-γ and LPS are also suppressed by 3,4-DAA at concentration of 30-200 µM. Mice with experimental autoimmune encephalomyelitis treated orally (300 mg/kg per day) with 3,4-DAA exhibited fewer and milder relapses and less severe disease compared to control animals.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Platten, M.,ho, P.P.,Youssef, S., et al. Treatment of autoimmune neuroinflammation with a synthetic tyrptophan metabolite. Science 310, 850-855 (2005).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 343.3 |
| 分子式 | C18H17NO6 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
