| 货号 | 70655-1mg |
| 描述 | SC-58125 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK 966 (rofecoxib), DUP-697, and celecoxib. SC-58125 is a potent and time-dependent inhibitor of COX-2.1 When tested on the isolated recombinant enzymes, SC-58125 is at least 150 times more potent in the inhibition of COX-2 as COX-1.2 In cultured HUVEC cells, SC-58125 inhibits COX-2 with an IC50 of 70 nM.3 It also inhibits the growth of the COX-2 expressing cell line HCA-7 in nude mice at 5-10 mg/kg when given intraperitoneally.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Seibert, K.,Zhang, Y.,Leahy, K., et al. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proceedings of the National Academy of Sciences of the United States of America 91, 12013-12017 (1994). 2.Anderson, G.D.,Hauser, S.D.,McGarity, K.L., et al. Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis. Journal of Clinical Investigation 97, 2672-2679 (1996). 3.Miralpeix, M.,Camacho, M.,López-Belmonte, J., et al. Selective induction of cyclo-oxygenase-2 activity in the permanent human endothelial cell line HUV-EC-C: Biochemical and pharmacological characterization. British Journal of Pharmacology 121, 171-180 (1997). 4.Sheng, H.,Shao, J.,Kirkland, S.C., et al. Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. Journal of Clinical Investigation 99, 2254-2259 (1997). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 384.3 |
| 分子式 | C17H12F4N2O2S |
| CAS号 | 162054-19-5 |
| 稳定性 | ≥ 1 year |
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