2-Linoleoyl Glycerol
货号：
62260-500ug 基本售价：
154.0 元 规格：
500 ug
产品信息
概述| 货号 | 62260-500ug |
| 描述 | 2-Arachidonoyl glycerol (2-AG) has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the CB1receptor.1,2 The congener of 2-AG in which a linoleoyl group replaces the arachidonoyl group is 2-linoleoyl glycerol (2-LG), and this compound also appears in vivo in conjunction with 2-AG.3 Although the intrinsic activity of 2-LG is low, it potentiates the activity of other endocannabinoids, including 2-AG. This “entourage” effect has been attributed to blockade of the breakdown and reuptake pathways that normally function to reduce endocannabinoid levels rapidly upon release. |
| 别名 | 2-LG; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sugiura, T.,Kodaka, T.,Kondo, S., et al. 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma X glioma hybrid NG108-15 cells. Biochemical and Biophysical Research Communications 229, 58-64 (1996).
2.Sugiura, T.,Kodaka, T.,Kondo, S., et al. Is the cannabinoid CB1 receptor a 2-arachidonoylglycerol receptor? Structural requirements for triggering a Ca2+ transient in NG108-15 cells. Journal of Biochemistry 122, 890-895 (1997).
3.Ben-Shabat, S.,Fride, E.,Sheskin, T., et al. An entourage effect: Inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity. European Journal of Pharmacology 353, 23-31 (1998).
|
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% (as a 9:1 mixture of the 2-LG and 1-LG) |
| 计算分子量 | 354.5 |
| 分子式 | C21H38O4 |
| CAS号 | 3443-82-1 |
| 稳定性 | ≥ 6 months |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
