C-16 Ceramide
货号：
10681-1mg 基本售价：
140.0 元 规格：
1 mg
产品信息
概述| 货号 | 10681-1mg |
| 描述 | Ceramides are generated from sphingomyelin through activation of sphingomyelinases or through the de novo synthesis pathway, which requires coordinate action of serine palmitoyl transferase and ceramide synthase. They have been shown to mediate antiproliferative responses such as apoptosis, growth arrest, differentiation, and senescence.1 C-16 ceramide is an endogenous ceramide, generated by ceramide synthase 6 (CerS6), that acts a lipid second messenger to regulate apoptosis and stress signaling.2 Accumulation of C-16 ceramide through PPMP (30 μM) or MAPP (50 μM) treatment or from addition of 100 μM synthetic C-16 ceramide induces apoptosis in neutrophil cultures via caspase-3 activation.3 |
| 别名 | C16 Ceramide (d18:1/16:0);N-palmitoyl-D-erythro-sphingosine;Palmitoyl Ceramide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ogretmen, B.,Pettus, B.J.,Rossi, M.J., et al. Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A547 human lung adenocarcinoma cell line. The Journal of Biological Chemisty 277(15), 12960-12969 (2002).
2.White-Gilbertson, S.,Mullen, T.,Senkal, C., et al. Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase 3 in colon cancer cells. Oncogene 28(8), 1132-1141 (2009).
3.Seumois, G.,Fillet, M.,Gillet, L., et al. De novo C16- and C24-ceramide generation contributes to spontaneous neutrophil apoptosis. Journal of Leukocyte Biology 81, 1477-1486 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 537.9 |
| 分子式 | C34H67NO3 |
| CAS号 | 24696-26-2 |
| 稳定性 | ≥ 2 years |
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