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货号： bs-12132R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-12132R-PE-Cy7
- 英文名称
- Anti-ASIC3/PE-Cy7
- 中文名称
- PE-Cy7标记的酸敏感离子通道蛋白3抗体
- 别 名
- ASICs3; ACCN 3; ACCN3; ASIC3_HUMAN; Acid sensing ion channel 3; Acid-sensing ion channel 3; Amiloride sensitive cation channel 3; Amiloride sensitive cation channel 3 testis; Amiloride-sensitive cation channel 3; ASIC 3; ASIC3; DRASIC; hASIC 3; hASIC3; hTNaC 1; hTNaC1; Modulatory subunit of ASIC 2a; Modulatory subunit of ASIC2a; Neuronal amiloride sensitive cation channel 3; Neuronal amiloride-sensitive cation channel 3; Proton gated cation channel subunit; SLNAC 1; SLNAC1; Testis sodium channel 1; TNaC 1; TNaC1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 神经生物学 通道蛋白 细胞膜受体
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Horse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 59kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human ASIC3 (342-420aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.
Function:
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.
Subunit:
Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM and DLG4 (By similarity). Interacts with LIN7B, MAGI1/BAIAP1, GOPC and ASIC2.
Subcellular Location:
Cell membrane. Cytoplasm. Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells.
Tissue Specificity:
Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis.
Post-translational modifications:
Phosphorylated by PKA. Phosphorylated by PKC. In vitro, PRKCABP/PICK-1 is necessary for PKC phosphorylation and activation of a ACCN3/ASIC3-ACCN1/ASIC2b channel, but does not activate a homomeric ACCN3 channel.
DISEASE:
Expressed in fetal tissues, expression increases in lung and kidney adult tissues.
Similarity:
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ACCN3 subfamily.
Database links:Entrez Gene: 9311Human
Entrez Gene: 171209Mouse
Entrez Gene: 286920Rat
Omim: 611741Human
SwissProt: Q9UHC3Human
SwissProt: Q6X1Y6Mouse
SwissProt: O35240Rat
Unigene: 647113Human
Unigene: 299636Mouse
Unigene: 24225Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.