| 货号 | 10008869-25mg |
| 描述 | Platelet-activating factor (PAF) is a biologically active phospholipid synthesized by a variety of stimulated cells that acts as a mediator of platelet aggregation, inflammation, and allergy.1,2 PAF is converted to the biologically inactive lyso-PAF by the enzyme PAF acetylhydrolase (PAF-AH). Recently, plasma PAF-AH has been linked to atherosclerosis and may be a positive risk factor for coronary heart disease in humans.3 1-Linoleoyl glycerol (1-LG) is a fatty acid glycerol that has been isolated from S. chinensis roots. It inhibits PAF-AH with an IC50 of 45 µM.4 1-LG has potential application in cholesterol lowering and antiatherogenic activity. |
| 别名 | 1-LG; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Prescott, S.M.,Zimmerman, G.A., and McIntyre, T.M. Platelet-activating factor. The Journal of Biological Chemisty 265, 17381-17384 (1990). 2.Snyder, F. Platelet-activating factor and related acetylated lipids as potent biologically active cellular mediators. American Journal of Physiology.Cell Physiology 259, C697-C708 (1990). 3.Caslake, M.J., and Packard, C.J. Lipoprotein-associated phospholipase A2 (platelet-activating factor acetylhydrolase) and cardiovascular disease. Current Opinion in Lipidology 14, 347-352 (2003). 4.Lee, W.S.,Kim, M.J.,Beck, Y.I., et al. Lp-PLA2 inhibitory activities of fatty acid glycerols isolated from Saururus chinensis roots. Bioorganic & Medicinal Chemistry Letters 15, 3573-3575 (2005). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥90% |
| 计算分子量 | 354.5 |
| 分子式 | C21H38O4 |
| CAS号 | 2258-92-6 |
| 稳定性 | ≥ 6 months |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |