| 货号 | 10007781-1mg |
| 描述 | D-myo-Inositol-1,3,5-phosphate (Ins(1,3,5)P3) is a member of the inositol phosphate (InsP) family of second messengers that play a critical role in the transmission of cellular signals.1,2 The most studied InsP, Ins(1,4,5)P3 is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate.3,4 Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium.4,5Ins(1,3,5)P3 (tested as the meso compound) is 50-fold less potent than Ins(1,4,5)P3 at initiating Ca2+ release when injected into Xenopusoocytes.6 |
| 别名 | Ins(1,3,5)P3 (sodium salt);1,3,5-IP3 (sodium salt); |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361, 315-325 (1993). 2.Majerus, P.W. Inositol phosphate biochemistry. Annual Reviews of Biochemistry 61, 225-250 (1992). 3.Streb, H.,Irvine, R.F.,Berridge, M.J., et al. Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature 306, 67-69 (1983). 4.Yoshida, Y., and Imai, S. Structure and function of inositol 1,4,5-triphosphate receptor. Japanese Journal of Pharmacology 74, 125-137 (1997). 5.Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annual Reviews of Pharmacology and Toxicology 36, 481-509 (1996). 6.DeLisle, S.,Radenberg, T.,Wintermantel, M.R., et al. Second messenger specificity of the inositol trisphosphate receptor: Reappraisal based on novel inositol phosphates. American Journal of Physiology.Cell Physiology 35, C429-C436 (1994). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 486 |
| 分子式 | C6H12O15P3 ?3Na |
| 稳定性 | ≥ 1 year |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |