| 货号 | 10010333-1mg |
| 描述 | Misoprostol (free acid)-d5 contains five deuterium atoms at the 16 methyl, 17, and 17 positions. It is intended for use as an internal standard for the quantification of misoprostol (free acid) by GC- or LC-mass spectrometry (MS). Misoprostol is a PGE1 analog with agonist activity mediated by EP2, EP3, and EP4receptors.1,2,3,4 It has been shown to inhibit the formation of gastric lesions in rats (ED50 = 0.31 µg/kg),2 inhibit superoxide generation in human neutrophils (EC50 = 0.35 µM),3 and relax fetal rabbit ductus arteriosus (EC50 = 0.36 nM)4 in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with RU-486 for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid.1 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Walt, R.P. Misoprostol for the treatment of peptic ulcer and antiinflammatory-drug-induced gastroduodenal ulceration. New England Journal of Medicine 327, 1575-1580 (1992). 2.Bunce, K.T.,Clayton, N.M.,Coleman, R.A., et al. GR63799X - a novel prostanoid with selectivity for EP3 receptors. Advances in Prostaglandin, Thromboxane, and Leukotriene Research 21, 379-382 (1990). 3.Talpain, E.,Armstrong, R.A.,Coleman, R.A., et al. Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils. British Journal of Pharmacology 114, 1459-1465 (1995). 4.Smith, G.C.S.,Coleman, R.A., and McGrath, J.C. Characterization of dilator prostanoid receptors in the fetal rabbit ductus arteriosus. Journal of Pharmacology and Experimental Therapeutics 271, 390-396 (1994). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d5) |
| 计算分子量 | 373.5 |
| 分子式 | C21H31D5O5 |
| CAS号 | 1337917-44-8 |
| 稳定性 | ≥ 1 year |
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