CUDC-101
货号：
14060 基本售价：
7250.0 元 规格：
25 mg
产品信息
概述| 货号 | 14060 |
| 描述 | A novel hybrid dual-acting HDAC and receptor tyrosine kinase inhibitor. It is a potent HDAC inhibitor which also inhibits EGFR and HER2 (IC50 = 4.4 nM, 2.4 nM and 15.7 nM respectively) (ref 1). It not only blocks EGFR and HER2 but also attenuates multiple compensatory pathways such as AKT, HER3 and MET which enable tumor cells to escape the effects of conventional EGFR/HER2 inhibitors (ref 1,2). |
| 别名 | CUDC101, 7-((4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide |
性能| 供应商 | Active Motif |
| 运输条件 | Blue Ice |
| 存放说明 | Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month. |
| 外观 | White to off-white powder. May be dissolved in DMSO (25 mg/ml). |
| 参考文献 | 1. CJ Lai et al. Cancer Res. 2010, 70:3647
2. X Cai et al. J. Med. Chem. 2010, 53:2000
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参考图片Chemical structure of CUDC-101. |
