| 货号 | 14072 |
| 描述 | BIX-01294 is a selective inhibitor of G9a histone methyltransferase (IC50 = 1.7 µM) as well as GLP histone methyltransferase (IC50 = 38 µM) leading to a decrease in histone H3 lysine 9 methylation (H3K9me2) in vitro (ref 1). It facilitates the reactivation of pluripotency genes and induces passive demethylation, thus promoting reprogramming (ref 2). BIX-01294, in combination with BAY K8644 (a calcium channel agonist), was found to improve reprogramming efficiencies of Oct4-Klf4-(OK)-infected neural progenitor cells (ref 3). It induced apoptosis and decreased proliferation, mobility and invasion in human neuroblastoma cells (ref 4). |
| 别名 | BIX-01294 3HCl, 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride |
| 供应商 | Active Motif |
| 运输条件 | Blue Ice |
| 存放说明 | Store desiccated as supplied at room temperature for up to 2 years. Store solutions at -20°C for up to 3 months. |
| 纯度 | >98% (TLC); NMR (Conforms) |
| 计算分子量 | 600.0 |
| 分子式 | C28H38N6O2 |
| CAS号 | 935693-62-2 |
| 外观 | Off white crystalline solid. May be dissolved in DMSO (50 mg/ml); Water (50 mg/ml). |
| 参考文献 | 1. S Kubicek et al. Mol. Cell 2007, 25:473 2. D Huangfu et al. Nat. Biotechnol. 2008, 26:795 3. Y Shi et al. Cell Stem Cell 2008, 2:525 4. Z Lu et al. Anticancer Drugs 2013, 24:484 |
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Chemical structure of BIX-01294 3HCl. |
