| 货号 | 14084 |
| 描述 | Potent and selective histone deacetylase 6 (HDAC 6) inhibitor (IC50 = 15 nm; >1000-fold selective against other HDACs and 60-fold for HDAC8))(ref 1). Inhibits TNFα (IC50 = 272 nm) and IL-6 (IC50 = 712 nm) in LPS-stimulated human macrophages and displays anti-inflammatory activity in animal models (ref 2). Improves survival in animal models of sepsis (ref 3). Improves cognition in Alzheimers disease transgenic mice (ref 4). Cell permeable. |
| 别名 | Tubastatin A, N-Hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]-indol-5(2H)-yl)methyl)benzamide, hydrochloride |
| 供应商 | Active Motif |
| 运输条件 | Blue Ice |
| 存放说明 | Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months. |
| 纯度 | 99% (HPLC); NMR (Conforms) |
| 计算分子量 | 371.9 |
| 分子式 | C20H21N3O2 |
| CAS号 | 1310693-92-5 |
| 外观 | White powder. May be dissolved in DMSO (50 mg/ml). |
| 参考文献 | 1. KV Butler et al. J. Am. Chem. Soc. 2010, 132:10842 2. S Vishwakarma et al. Int. Immunopharmacol. 2013, 16:72 3. T Zhao et al. Surg. Res. 2014, 190:647 4. L Zhang et al. J. Alzheimers Dis. 2014, 41:1193 |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
Chemical structure of Tubastatin A hydrochloride. |
