SirtAct
货号：
14080 基本售价：
5510.0 元 规格：
25 mg
产品信息
概述| 货号 | 14080 |
| 描述 | Sirt1 activator. It suppressed TNFα release from THP-1 cells and stimulated adipogenesis in 3T3L1 cells (ref 1). SIRT1 stimulation by SirtAct leads to decreased tissue factor mediated thrombogenicity in mice (ref 2). It inhibited NFκB activation and reduced inflammatory cytokine production in lamina propria mononuclear cells from IBD patients (ref 3). It prevented and cured experimental Colitis in a mouse model (ref 3). |
| 别名 | SirtAct, Sirt1 activator 3, CAY10591, 2-Amino-N-cyclopentyl-1-(3-methoxypropyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide |
性能| 供应商 | Active Motif |
| 运输条件 | Blue Ice |
| 存放说明 | Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months. |
| 纯度 | Physical Properties: Olive green powder>98% (TLC); NMR (Conforms) |
| 计算分子量 | 367.4 |
| 分子式 | C20H25N5O2 |
| CAS号 | 839699-72-8 |
| 外观 | Olive green powder. May be dissolved in DMSO (50 mg/ml); Ethanol (20 mg/ml, warm). |
| 参考文献 | 1. VM Nayagam et al. J. Biomol. Screen. 2006, 11:959
2. SS Barbieri et al. Circulation 2012, 126:1373
3. R Caruso et al. Mucosal Immunol. 2014, May 21 Epub
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参考图片Chemical structure of Garcinol. |
