| 货号 | 14122 |
| 描述 | Potent and selective inhibitor of the protein lysine methyltransferase SETD8 (IC50 = 0.21 µM) which efficiently suppresses cellular H4K20me1 at doses lower than 5 µM (ref 1). Also inhibits CDC25 phosphatases (ref 2). Arrests cells at G1 and G2/M and inhibits cdk1 and 2 activation (ref 3). Inhibits the growth of a variety of human tumor cell lines (ref 4). |
| 别名 | NSC-663284, 6-Chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione |
| 供应商 | Active Motif |
| 运输条件 | Blue Ice |
| 存放说明 | Store desiccated as supplied at -20° for up to 2 years. Store solutions at -20°C for up to 1 month. |
| 纯度 | >98% (TLC); NMR (Conforms) |
| 计算分子量 | 321.8 |
| 分子式 | C15H16ClN3O3 |
| CAS号 | 383907-43-5 |
| 外观 | Red powder. May be dissolved in DMSO (15 mg/ml); or ethanol (55 mg/ml). |
| 参考文献 | 1. G Blum et al. ACS Chem. Biol. 2014, 9:2471 2. JS Lazo et al. J. Med. Chem. 2001, 44:4042 3. L Pu et al. J. Biol. Chem. 2002, 277:46877 4. Y Han et al. J. Pharmacol. Exp. Ther. 2004, 309:64 |
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