| 货号 | 14074 |
| 描述 | Selective sirtuin inhibitor which does not effect HDAC1 (IC50 = 131 M, 38 M and 68 M for SIRT1, SIRT2 and Sir2P respectively) (ref 1). Induces apoptotic and autophagic cell death in MCF-7 human breast cancer cell lines (ref 2). Suppresses survivin expression which correlates with decreased viability in HT29 colon cancer cells (ref 3). Displays pro-inflammatory effects in adipocytes (ref 4). |
| 别名 | 2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide |
| 供应商 | Active Motif |
| 运输条件 | Blue Ice |
| 存放说明 | Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month. |
| 纯度 | >98% (TLC); NMR (Conforms) |
| 计算分子量 | 394.5 |
| 分子式 | C26H22N2O2 |
| CAS号 | 410536-97-9 |
| 外观 | Yellow powder. May be dissolved in DMSO (35 mg/ml); Ethanol (10 mg/ml). |
| 参考文献 | 1. CM Grosinger et al. J. Biol. Chem. 2001, 276:38837 2. J Wang et al. Int. J. Oncol. 2012, 41:1101 3. YF Hsu et al. Biochim. Biophys. Acta 2012, 1820:104 4. QQ Lin et al. Cytokine 2012, 60:447 |
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Chemical structure of Sirtinol. |
