GSK-J1 (cell impermeable)
货号：
14068 基本售价：
4640.0 元 规格：
25 mg
产品信息
概述| 货号 | 14068 |
| 描述 | A potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM, human JMJD3). This is the first known inhibitor selective for the H3K27me3-specific JMJ subfamily which binds to the active catalytic site of the enzyme. The COOH group confers cell impermeability and as such is useful as a standard in vitro assay. A cell permeable ethyl ester analog is also available (Catalog No. 14070).
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| 别名 | N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine |
性能| 供应商 | Active Motif |
| 运输条件 | Blue Ice |
| 存放说明 | Store desiccated as supplied at room temperature for up to 2 years. Store solutions at -20°C for up to 3 months. |
| 外观 | Pale yellow powder. May be dissolved in DMSO (20 mg/ml, warm). |
| 参考文献 | 1. L Kruidenier et al. Nature 2012, 488:404
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参考图片Chemical structure of GSK-J1. |
