| 货号 | 14136 |
| 描述 | Class I, isoform-selective HDAC inhibitor (IC50 = 0.15, 0.29, 1.66 and 0.59 µM for HDAC1, 2, 3 and 11 respectively) (ref 1). Induces hyperacetylation of histones, induces expression of the tumor supressor p21WAF1 and inhibits proliferation of human cancer cells (ref 2). Displays antifibrotic effects in ischemic heart failure (ref 3). Attenuates the development of hypersensitivity in models of neuropathic pain (ref 4). Active in vivo (ref 5). |
| 别名 | Mocetinostat; N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide; MGCD010 |
| 供应商 | Active Motif |
| 运输条件 | Blue Ice |
| 纯度 | >98% (HPLC); NMR (Conforms) |
| 计算分子量 | 396.4 |
| 分子式 | C23H20N6O |
| CAS号 | 726169-73-9 |
| 外观 | Off-white crystalline powder. May be dissolved in DMSO (25 mg/ml). |
| 参考文献 | 1. N Zhou et al. J. Med. Chem. 2008, 51:4072 2. S Raeppel et al. Bioorg. Med. Chem. Lett. 2009, 19:644 3. H Nural-Govener et al. Int. J. Mol. Sci. 2015, 16:11482 4. F Denk et al. Pain 2013, 154:1668 5. C Bonfils et al. Clin. Cancer Res. 2008, 14:3441 |
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