| 货号 | 14092 |
| 描述 | Orally active histone deacetylase (HDAC) inhibitor (IC50 = 0.9, 0.9, 1.2, and >20 µM for HDAC1, HDAC2, HDAC3 and HDAC8 respectively) (ref1). Mediates G1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitroandin vivo (ref 2,3). Increase neuroplasticity during memory extinction (ref 4). Protects beta cells from cytokine-induced apoptosis (ref 4). |
| 别名 | N-acetyl-dinaline; 4-(Acetylamino)-N-(2-aminophenyl)benzamide; PD-123654 |
| 供应商 | Active Motif |
| 运输条件 | Blue Ice |
| 存放说明 | Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month. |
| 纯度 | >98% (TLC); NMR (Conforms) |
| 计算分子量 | 269.3 |
| 分子式 | C15H15N3O2 |
| CAS号 | 112522-64-2 |
| 外观 | Off-white powder. May be dissolved in DMSO (25 mg/ml). |
| 参考文献 | 1. OM Moradei et al. J. Med. Chem. 2007, 50:5543 2. T Beckers et al. Int. J. Cancer 2007, 121:1138 3. M Loprevite et al. Oncol. Res. 2005, 15:39 4. DH Chou et al. Chem. Biol. 2012, 19:669 |
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Chemical structure of CI-994. |
