Apicidin
货号：
14040 基本售价：
3842.5 元 规格：
5 mg
产品信息
概述| 货号 | 14040 |
| 描述 | Cyclopeptide inhibitor of histone deacetylases (HDACs) (ref 1). Inhibits HeLa cell proliferation (IC50 = 50-100 nM) and induces reversible transcriptional activation of p21 (WAF1) (ref 2). Decreases HIF1α protein levels and transcriptional activity in human and mouse tumor cell lines (ref 3). Cell permeable. |
| 别名 | Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinexcarbonyl] |
性能| 供应商 | Active Motif |
| 运输条件 | Blue Ice |
| 存放说明 | Store desiccated as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
| 纯度 | ≥98% (HPLC); NMR (Conforms) |
| 计算分子量 | 623.8 |
| 分子式 | C34H49N5O6 |
| CAS号 | 183506-66-3 |
| 外观 | White solid. May be dissolved in DMSO (10 mg/ml). |
| 参考文献 | 1. SJ Darkin-Rattray et al. Proc. Natl. Acad. Sci. USA 1996, 93:13143
2. JW Han et al. Cancer Res. 2000, 60:6068
3. SH Kim et al. Oncol. Rep. 2007, 17:647
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参考图片Chemical structure of Apicidin. |
