AK-7
货号：
14054 基本售价：
3770.0 元 规格：
25 mg
产品信息
概述| 货号 | 14054 |
| 描述 | A selective Sirt2 inhibitor (IC50 = 15.5 M) which does not bind Sirt1 or Sirt3 (ref 1). It down-regulates cholesterol biosynthesis genes in primary striatal neurons (ref 1). Displays neuroprotective effects in Huntingtons disease mouse models including improved motor function, extended survival and reduce brain atrophy all of which were associated with reduced aggregated mutant huntingtin (ref 2). |
| 别名 | 3-(1-Azepanylsulfonyl)-N-(3-bromophenyl)benzamide |
性能| 供应商 | Active Motif |
| 运输条件 | Blue Ice |
| 存放说明 | Store desiccated as supplied at room temperature for up to 3 years. Store solutions at -20°C for up to 3 months. |
| 外观 | White powder. May be dissolved in DMSO (50 mg/ml); Ethanol (8 mg/ml, warm). |
| 参考文献 | 1. DM Taylor et al. ACS Chem. Biol. 2011, 6:540
2. V Chopra et al. Cell Rep. 2012, 2:1492
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参考图片Chemical structure of AK-7 |
