| 货号 | 14118 |
| 描述 | Inhibits the lysine acetyltransferase PCAF in vitroandin vivo(in vitroIC50 = 7.2 µM). Inhibits H3K9 acetylation in mouse liver tissue while leaving levels of H3K14, H4K8, and H4K12 unchanged (ref 1). Also inhibits X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 µM, competing with Smac peptide)(ref 2). Binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Induces apoptosis and alters gene expression profiles in breast cancer cells (ref 3). Possesses anti-inflammatory and analgesic activity in vivo (ref 4). Cell permeable. |
| 别名 | 2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione |
| 供应商 | Active Motif |
| 运输条件 | Blue Ice |
| 存放说明 | Store desiccated as supplied at -20° for up to 2 years. Store solutions at -20°C for up to 1 month. |
| 纯度 | MP = 142-143°C >98% (HPLC); NMR (Conforms) |
| 计算分子量 | 294.8 |
| 分子式 | C17H26O4 |
| CAS号 | 550-24-3 |
| 外观 | Dark orange powder. May be dissolved in DMSO (30 mg/ml); or ethanol (3 mg/ml, warm). |
| 参考文献 | 1. R Modak et al. ACS Chem. Biol. 2013, 8:1311 2. Z Nikolovska-Coleska et al. J. Med Chem. 2004, 47:2430 3. P Shaw et al. Pharmacol. Rep. 2016, 68:638 4. M Chitra et al. Chemotherapy 1994, 40:109 |
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