UNC1999
货号：
14114 基本售价：
3480.0 元 规格：
25 mg
产品信息
概述| 货号 | 14114 |
| 描述 | UNC1999 is an orally active, highly selective inhibitor of both wild-type and mutant EZH1 and EZH2 lysine methyltransferases (IC50 = 45 nM and 2 nM respectively)(ref 1). Inhibition of EZH2 with UNC1999 enhanced the efficacy of gefitinib in suppressing the proliferation of colon cancer cells (ref 2). It suppresses global H3K27 trimethylation/demethylation and inhibits the growth of mixed lineage leukemia (MLL)-rearranged leukemia cells (ref 3). |
| 别名 | N-{(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl}-1-propan-2-yl-6-{6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl}indazole-4-carboxamide |
性能| 供应商 | Active Motif |
| 运输条件 | Blue Ice |
| 存放说明 | Store desiccated as supplied at -20° for up to 2 years. Store solutions at -20°C for up to 3 months. |
| 纯度 | >98% (HPLC); NMR (Conforms) |
| 计算分子量 | 569.7 |
| 分子式 | C33H43N7O2 |
| CAS号 | 1431612-23-5 |
| 外观 | White powder. May be dissolved in DMSO (10 mg/ml). |
| 参考文献 | 1. KD Konze et al. ACS Chem. Biol. 2013, 8:1324
2. BW Katona et al. Cancer Biol. Ther. 2014, 15:1677
3. B Xu et al. Blood 2015, 125:346
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