JIB-04
货号：
14134 基本售价：
3262.5 元 规格：
25 mg
产品信息
概述| 货号 | 14134 |
| 描述 | A novel specific inhibitor of the Jumonji family of histone demethylases in vitro, in cancer cells and in tumors in vivo. IC50 = 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively. Reduces tumor burden and prolongs life in a mouse model (ref 1). Suppresses translation initiation and enhances mTOR inhibitor sensitivity (ref 2). Inhibits the growth of temozolomide-resistant glioblastoma cells and crosses the blood brain barrier (ref 3). |
| 别名 | JIB-04, JHDM Inhibitor VII, (E)-5-chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine |
性能| 供应商 | Active Motif |
| 运输条件 | Blue Ice |
| 存放说明 | Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 2 months. |
| 纯度 | >98% (TLC); NMR (Conforms) |
| 计算分子量 | 308.8 |
| 分子式 | C17H13ClN4 |
| CAS号 | 199596-05-9 |
| 外观 | Yellow powder. May be dissolved in DMSO (30 mg/ml). |
| 参考文献 | 1. L Wang et al. Nature Commun. 2013, 4:2035
2. C Can Rechem et al. Cancer Discov. 2015, 5:255
3. B Banelli et al. Oncotarget 2017, 8:34896
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