| 货号 | 14052 |
| 描述 | Potent and selective inhibitor of the histone acetyltransferase p300/CBP (Ki = 400 nM)(ref 1). Induces apoptosis in prostate cancer cells (ref 2). Enhances fear extinction memory and synaptic plasticity in mice (ref 3). Promotes tau deacetylation reducing levels of pathogenic p-tau (ref 4). Cell permeable. |
| 别名 | C-646, 4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid |
| 供应商 | Active Motif |
| 运输条件 | Blue Ice |
| 存放说明 | Store desiccated as supplied at 4°C for up to 2 years. Store solutions at -20°C for up to 2 months. |
| 纯度 | >98% (TLC); NMR (Conforms) |
| 计算分子量 | 445.4 |
| 分子式 | C24H19N3O6 |
| CAS号 | 328968-36-1 |
| 外观 | Orange powder. May be dissolved in DMSO (10 mg/ml). |
| 参考文献 | 1. EM Bowers et al. Chem. Biol. 2010, 17:471 2. FR Santer et al. Mol. Cancer Ther. 2011, 10:1644 3. R Marek et al. J. Neurosci. 2011, 31:7486 4. S-W Min et al. Neuron 2010, 67:953 |
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Chemical structure of C646 |
