AS-8351
货号：
14112 基本售价：
2900.0 元 规格：
25 mg
产品信息
概述| 货号 | 14112 |
| 描述 | AS-8351 has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts (ref 1). It is believed that AS-8351 exerts its effects by modulating the activity of the JmjC domain-containing histone demethylases (JmjC-KDM). Thus each of the 22 genes in the JmjC-KDM family was abrogated using small hairpin RNAs which showed that only knocking down KDM5B (or using another KDM5B inhibitor such as PBIT) could phenocopy AS-8351 in generating cardiomyocytes. This strongly suggests that KDM5B is the target of AS-8351 (ref 1).
|
| 别名 | AS-8351, 2-Hydroxy-1-naphthylaldehyde isonicotinoylhydrazone; NSC-5135 |
性能| 供应商 | Active Motif |
| 运输条件 | Blue Ice |
| 存放说明 | Store desiccated as supplied at -20° for up to 2 years. Store solutions at -20°C for up to 1 month. |
| 纯度 | MP = 262-264°C >98% (TLC); NMR (Conforms) |
| 计算分子量 | 291.3 |
| 分子式 | C17H13N3O2 |
| CAS号 | 796-42-9 |
| 外观 | Yellow powder. May be dissolved in DMSO (45 mg/ml); Ethanol (10 mg/ml, warm); or DMF (30 mg/ml). |
| 参考文献 | 1. N Cao et al. Science 2016, 352:1216
|
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
