| 货号 | 14082 |
| 描述 | A potent and selective inhibitor of class I histone deacetylases (HDACs), IC50 = 36, 47, 510 and 14,000 nM for HDAC1, 2, 4 and HDAC6 respectively (ref 1). Induces apoptosis in a variety of cell lines (ref 2) and displays anti-tumor activity in mouse models (ref 3). Recently approved for clinical uses in T-cell lymphoma (ref 4). |
| 别名 | Romidepsin, FK228, FK 228, FR901228, Depsipeptide |
| 供应商 | Active Motif |
| 运输条件 | Blue Ice |
| 存放说明 | Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month. |
| 纯度 | >98% (HPLC); NMR (Conforms) |
| 计算分子量 | 540.7 |
| 分子式 | C24H36N4O6S2 |
| CAS号 | 128517-07-7 |
| 外观 | Colorless lyophilized wax (vials appear empty). May be dissolved in DMSO (10 mg/ml). |
| 参考文献 | 1. R Furumai et al. Cancer Res. 2002, 62:4916 2. J Panicker et al. Cell Cycle 2010, 9:1830 3. H Ueda et al. J. Antibiot. (Tokyo) 1994, 47:315 4. MK VanderMolin et al. J. Antibiot. (Tokyo) 2011, 64:525 |
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