| 货号 | 14062 |
| 描述 | Inhibits PHD or prolyl hydroxylase domain-containing proteins, activating HIF1α (ref 1,2) and inhibiting JMJD2A (IC50 = 2.5 M) (ref 3). Displays neuroprotective effects. Inhibits neuronal cell death caused by neurotrophin deprivation (ref 4). Prevents activation of the ATR/CHK1/p53 pathway and suppresses apoptosis induced by DNA damage (ref 5). |
| 别名 | N-(2-Methyoxy-2-oxoacetyl)glycine methyl ester; Dimethyloxalylglycine |
| 供应商 | Active Motif |
| 运输条件 | Blue Ice |
| 存放说明 | Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month. |
| 纯度 | MP = 46-48°C>98% (TLC); NMR (Conforms) |
| 计算分子量 | 175.1 |
| 分子式 | C6H9NO5 |
| CAS号 | 89464-63-1 |
| 外观 | White to off-white solid. May be dissolved in DMSO (30 mg/ml); Ethanol (25 mg/ml); Water (30 mg/ml). |
| 参考文献 | 1. TM Asikainen et al. Proc. Natl. Acad. Sci. USA 2005, 102:10212 2. P Jaakkola et al. Science 2001, 292:468 3. S Hamada et al. Bioorg. Med. Chem. Lett. 2009, 19:2852 4. DJ Lomb et al. Mol. Pharmacol. 2009, 75:1198 5. L Xie et al. Clin. Invest. 2012, 122:2827 |
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Chemical structure of DMOG. |
