Salermide
货号：
14124 基本售价：
2320.0 元 规格：
25 mg
产品信息
概述| 货号 | 14124 |
| 描述 | SIRT1 and SIRT2 inhibitor. Exhibits a stronger inhibitory effect on SIRT2 than on SIRT1 in vitro. Induces the reactivation of proapoptotic genes repressed by SIRT1 and causes massive apoptosis in cancer cells within 24 hours (ref 1). Displays protective effect in nematodes expressing muscular dystrophy protein (ref 2). Promotes neuronal apoptosis confirming the protective effect of SIRT1 (ref 3). |
| 别名 | Salermide, N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-a-methylbenzeneacetamide |
性能| 供应商 | Active Motif |
| 运输条件 | Blue Ice |
| 存放说明 | Store desiccated as supplied at -20° for up to 2 years. Store solutions at -20°C for up to 1 month. |
| 纯度 | MP = 175-177°C >98% (TLC); NMR (Conforms) |
| 计算分子量 | 394.5 |
| 分子式 | C26H22N2O2 |
| CAS号 | 1105698-15-4 |
| 外观 | Yellow powder. May be dissolved in DMSO (40 mg/ml); ethanol (10 mg/ml; warm); or DMF (30 mg/ml). |
| 参考文献 | 1. E Lara et al. Oncogene 2009, 28:781
2. MY Pasco et al. J. Med. Chem. 2010, 53:1407
3. Y Zhao et al. Exp. Neurol. 2012, 237:489
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