| 货号 | 14026 |
| 描述 | Potent and selective histone deacetylase inhibitor (ref 1). Induces apoptosis in a variety of tumor cell lines (ref 2). Synergizes with kinase inhibitors to kill CNS tumor cells (ref 3). Prevents diabetes in a mouse model by immunoregulation and β-cell pretection (ref4). Cell permeable. |
| 别名 | Suberoylanilide-hydroxamic acid, SAHA |
| 供应商 | Active Motif |
| 运输条件 | Blue Ice |
| 存放说明 | Store desiccated as supplied at room temperature for up to 5 years. Store solutions at -20°C for up to 1 month. |
| 纯度 | >98% (TLC); NMR (Conforms) |
| 计算分子量 | 264.3 |
| 分子式 | C14H20N2O3 |
| CAS号 | 149647-78-9 |
| 外观 | White powder. May be dissolved in DMSO (50 mg/ml); Ethanol (2 mg/ml). |
| 参考文献 | 1. JA Vrana et al. Oncogene 1999, 18:7016 2. LM Butler et al. Proc. Natl. Acad. Sci. USA 2002, 99:11700 3. Y Tang et al. Cancer Biol. Ther. 2012, 13:567 4. DP Christensen et al. Proc. Natl. Acad. Sci. USA 2014, 111:1055 |
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Chemical structure of Vorinostat (SAHA). |
