PBIT
货号：
14111 基本售价：
942.5 元 规格：
5 mg
产品信息
概述| 货号 | 14111 |
| 描述 | The JARID1 (Jumonji AT-Rich Interactive Domain 1) family of lysine demethylases is responsible for demethylation of trimethylated lysine 4 in histone H3 (H3K4me3). PBIT is a potent and selective inhibitor of JARID1 (IC50 = 3, 4.9 and 6 µM for JARID1B, 1A and 1C, respectively). Selective for JARID1 over UTX and JMJD3. Treatment of cells with PBIT inhibits the demethylation of H3K4me3. It inhibits proliferation of breast cancer cell lines expressing high levels of JARID1B (ref 1). |
性能| 供应商 | Active Motif |
| 运输条件 | Blue Ice |
| 存放说明 | Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month. |
| 纯度 | >98% (TLC); NMR (Conforms) |
| 计算分子量 | 241.3 |
| 分子式 | C14H11NOS |
| CAS号 | 2514-30-9 |
| 外观 | Off-white powder. May be dissolved in DMSO (24 mg/ml); or ethanol (5 mg/ml). |
| 参考文献 | 1. J Sayegh et al. J. Biol. Chem. 2013, 288:9408
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参考图片Chemical structure of PBIT. |
