| 货号 | 14043 |
| 描述 | A potent and selective non-hydroxamate HDAC inhibitor. Considered to be a class I selective inhibitor but displays some selectivity amongst class I members; HDAC1 (IC50 = 0.3 M); HDAC3 (IC50 = 8 M) with no inhibition of HDAC 8 (at > 100 M) (ref 1). Induces hyperacetylation of nuclear histones in tumor cells resulting in inhibition of proliferation of a variety of human tumor cell lines (ref 2). Protects p53-deficient mice against ischemic injury (ref 3). Suppresses the p38 MAP kinase pathway in rheumatoid arthritic synovial fibroblasts (ref 4). Active in vivo. |
| 供应商 | Active Motif |
| 运输条件 | Blue Ice |
| 存放说明 | Store desiccated as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 1 week. |
| 纯度 | ≥98% (TLC); NMR (Conforms) |
| 计算分子量 | 376.4 |
| 分子式 | C21H20N4O3 |
| CAS号 | 209783-80-2 |
| 外观 | Pale yellow powder. May be dissolved in DMSO (25 mg/ml, warm). |
| 参考文献 | 1. E Hu et al. J. Pharmacol. Exp. Ther. 2003, 307:720 2. A Saito et al. Proc. Natl. Acad. Sci. USA 1999, 96:4592 3. SP Murphy et al. J. Neurochem. 2013, Oct 21 epub 4. QY Choo et al. Molecules 2013, 18:14085 |
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Chemical structure of MS-275. |
