Splitomicin
货号：
14087 基本售价：
725.0 元 规格：
5 mg
产品信息
概述| 货号 | 14087 |
| 描述 | Initially shown to inhibit Sir2p (the yeast Sirt1 homolog) and create a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae (ref 1). Cells grown in the presence of the drug have silencing defects at telomeres, silent mating-type loci and the ribosomal DNA (ref 1). Inhibits all class III HDACs (sirtuins) and alleviates gene silencing in Fragile X mental retardation syndrome (ref 2). Reverses ischemic preconditioning-induced cardioprotection in a mouse model (ref 3). |
性能| 供应商 | Active Motif |
| 运输条件 | Blue Ice |
| 存放说明 | Store desiccated as supplied at room temperature for up to 2 years. Store solutions at -20°C for up to 1 month. |
| 纯度 | >98% (TLC); NMR (Conforms) |
| 计算分子量 | 198.2 |
| 分子式 | C13H10O2 |
| CAS号 | 5690-03-9 |
| 外观 | White powder. May be dissolved in DMSO (>25 mg/ml); Ethanol (>25 mg/ml). |
| 参考文献 | 1. A Bedalov et al. Proc. Natl. Acad. Sci. USA 2001, 98:15113
2. R Biacsi et al. PLoS Genet. 2008, 4(3):e1000017
3. SM Nadtochiy et al. Cardiovasc. Res. 2011, 89:643
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参考图片Chemical structure of Splitomicin. |
