| 货号 | 14047 |
| 描述 | Irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) (IC50 less than 2 µM) (ref 1,2). Tranylcypromine treatment of P19 embryonal carcinoma cells resulted in global increase of H3K4 methylation along with transcriptional derepression of two BHC110 target genes, Egr1 and Oct4. When combined with CHIR99021, induces the generation of human-induced pluripotent stem cells in the absence of Sox2 (ref 3). Reduces proliferation, cell cycle progression and invasiveness of endometriotic stromal cells (ref 4). Upregulates CD86 expression in THP1 cells (ref 5). Cell permeable and active in vivo. |
| 供应商 | Active Motif |
| 运输条件 | Blue Ice |
| 存放说明 | Store desiccated as supplied at room temperature for up to 2 years. Store solutions at -20°C for up to 1 month. |
| 纯度 | >98% (TLC); NMR (Conforms) |
| 计算分子量 | 182.2 |
| 分子式 | C9H11N • 1/2 H2SO |
| CAS号 | 13492-01-8 |
| 外观 | White solid. May be dissolved in water (25 mg/ml). |
| 参考文献 | 1. NG Lee et al. Bhem. Biol. 2006, 13:563 2. DM Schmidt and DG McCaffertyBiochemistry 2007, 46:4408 3. W Li et al. Stem Cells 2009, 27:2992 4. D Ding et al. Fertil. Steril. 2014, 101:740 5. JT Lynch et al. Anal. Biochem. 2013, 442:104 |
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Chemical structure of Tranylcypromine hemisulfate. |
